Severe Acute Respiratory Syndrome Coronavirus Infection in Vaccinated Ferrets
Identifieur interne : 003800 ( Main/Exploration ); précédent : 003799; suivant : 003801Severe Acute Respiratory Syndrome Coronavirus Infection in Vaccinated Ferrets
Auteurs : Miriam E. R. Darnell ; Ewan P. Plant ; Hisayoshi Watanabe ; Russ Byrum [États-Unis] ; Marisa St. Claire [États-Unis] ; Jerrold M. Ward ; Deborah R. Taylor [États-Unis]Source :
- The Journal of Infectious Diseases [ 0022-1899 ] ; 2007.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Foie, Poumon.
- immunologie : Vaccins antiviraux, Virus du SRAS.
- sang : Anticorps antiviraux.
- Animaux, Facteurs temps, Femelle, Furets, Poids du corps, Production d'anticorps, Syndrome respiratoire aigu sévère, Température du corps.
- Pascal (Inist)
- Wicri :
- topic : Vaccin.
English descriptors
- KwdEn :
- Animals, Antibodies, Viral (blood), Antibody Formation, Body Temperature, Body Weight, Coronavirus, Female, Ferrets, Liver (pathology), Lung (pathology), SARS Virus (immunology), Severe Acute Respiratory Syndrome (prevention & control), Severe acute respiratory syndrome, Time Factors, Vaccine, Viral Vaccines (immunology).
- MESH :
- chemical , blood : Antibodies, Viral.
- immunology : SARS Virus, Viral Vaccines.
- pathology : Liver, Lung.
- prevention & control : Severe Acute Respiratory Syndrome.
- Animals, Antibody Formation, Body Temperature, Body Weight, Female, Ferrets, Time Factors.
Abstract
Background. Development of vaccines to prevent severe acute respiratory syndrome (SARS) is limited by the lack of well-characterized animal models. Previous vaccine reports have noted robust neutralizing antibody and inflammatory responses in ferrets, resulting in enhanced hepatitis. Methods. We evaluated the humoral immune response and pathological end points in ferrets challenged with the Urbani strain of SARS-associated coronavirus (SARS-CoV) after having received formalin-inactivated whole-virus vaccine or mock vaccine. Results. Humoral responses were observed in ferrets that received an inactivated virus vaccine. Histopathological findings in lungs showed that infection of ferrets produced residual lung lesions not seen in both mock and vaccinated ferrets. SARS-CoV infection demonstrated bronchial and bronchiolar hyperplasia and perivascular cuffing in ferret lung tissue, as seen previously in infected mice. No evidence of enhanced disease was observed in any of the ferrets. All of the ferrets cleared the virus by day 14, 1 week earlier if vaccinated. Conclusions. The vaccine provided mild immune protection to the ferrets after challenge; however, there was no evidence of enhanced liver or lung disease induced by the inactivated whole-virus vaccine. The ferret may provide another useful model for evaluating SARS vaccine safety and efficacy.
Url:
- https://api.istex.fr/ark:/67375/HXZ-Z9Z51LFK-Q/fulltext.pdf
- http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7110120
DOI: 10.1086/522431
Affiliations:
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Le document en format XML
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R." last="Darnell">Miriam E. R. Darnell</name><affiliation><wicri:noCountry code="subField">Bethesda</wicri:noCountry></affiliation></author><author><name sortKey="Plant, Ewan P" sort="Plant, Ewan P" uniqKey="Plant E" first="Ewan P." last="Plant">Ewan P. Plant</name><affiliation><wicri:noCountry code="subField">Bethesda</wicri:noCountry></affiliation></author><author><name sortKey="Watanabe, Hisayoshi" sort="Watanabe, Hisayoshi" uniqKey="Watanabe H" first="Hisayoshi" last="Watanabe">Hisayoshi Watanabe</name><affiliation><wicri:noCountry code="subField">Bethesda</wicri:noCountry></affiliation></author><author><name sortKey="Byrum, Russ" sort="Byrum, Russ" uniqKey="Byrum R" first="Russ" last="Byrum">Russ Byrum</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Bioqual, Inc., Rockville</wicri:cityArea></affiliation></author><author><name sortKey="St Claire, Marisa" sort="St Claire, Marisa" uniqKey="St Claire M" first="Marisa" last="St. Claire">Marisa St. Claire</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Bioqual, Inc., Rockville</wicri:cityArea></affiliation></author><author><name sortKey="Ward, Jerrold M" sort="Ward, Jerrold M" uniqKey="Ward J" first="Jerrold M." last="Ward">Jerrold M. Ward</name><affiliation><wicri:noCountry code="subField">Bethesda</wicri:noCountry></affiliation></author><author><name sortKey="Taylor, Deborah R" sort="Taylor, Deborah R" uniqKey="Taylor D" first="Deborah R." last="Taylor">Deborah R. Taylor</name><affiliation></affiliation><affiliation></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">Maryland</region></placeName><wicri:cityArea>Reprints or correspondence: Dr. Deborah R. Taylor, Laboratory of Hepatitis and Related Emerging Agents, Div. of Emerging and Transfusion-Transmitted Diseases, Office of Blood Research and Review, CBER FDA, 8800 Rockville Pike, HFM-310, NIH Bldg. 29A, 1C-14, Bethesda</wicri:cityArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Infectious Diseases</title><title level="j" type="abbrev">The Journal of Infectious Diseases</title><idno type="ISSN">0022-1899</idno><idno type="eISSN">1537-6613</idno><imprint><publisher>The University of Chicago Press</publisher><date type="published">2007</date><biblScope unit="vol">196</biblScope><biblScope unit="issue">9</biblScope><biblScope unit="page" from="1329">1329</biblScope><biblScope unit="page" to="1338">1338</biblScope></imprint><idno type="ISSN">0022-1899</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antibodies, Viral (blood)</term><term>Antibody Formation</term><term>Body Temperature</term><term>Body Weight</term><term>Coronavirus</term><term>Female</term><term>Ferrets</term><term>Liver (pathology)</term><term>Lung (pathology)</term><term>SARS Virus (immunology)</term><term>Severe Acute Respiratory Syndrome (prevention & control)</term><term>Severe acute respiratory syndrome</term><term>Time Factors</term><term>Vaccine</term><term>Viral Vaccines (immunology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Anticorps antiviraux (sang)</term><term>Facteurs temps</term><term>Femelle</term><term>Foie (anatomopathologie)</term><term>Furets</term><term>Poids du corps</term><term>Poumon (anatomopathologie)</term><term>Production d'anticorps</term><term>Syndrome respiratoire aigu sévère ()</term><term>Température du corps</term><term>Vaccins antiviraux (immunologie)</term><term>Virus du SRAS (immunologie)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Foie</term><term>Poumon</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Vaccins antiviraux</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>SARS Virus</term><term>Viral Vaccines</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Liver</term><term>Lung</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Antibody Formation</term><term>Body Temperature</term><term>Body Weight</term><term>Female</term><term>Ferrets</term><term>Time Factors</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Facteurs temps</term><term>Femelle</term><term>Furets</term><term>Poids du corps</term><term>Production d'anticorps</term><term>Syndrome respiratoire aigu sévère</term><term>Température du corps</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term><term>Syndrome respiratoire aigu sévère</term><term>Vaccin</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Vaccin</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Background. Development of vaccines to prevent severe acute respiratory syndrome (SARS) is limited by the lack of well-characterized animal models. Previous vaccine reports have noted robust neutralizing antibody and inflammatory responses in ferrets, resulting in enhanced hepatitis. Methods. We evaluated the humoral immune response and pathological end points in ferrets challenged with the Urbani strain of SARS-associated coronavirus (SARS-CoV) after having received formalin-inactivated whole-virus vaccine or mock vaccine. Results. Humoral responses were observed in ferrets that received an inactivated virus vaccine. Histopathological findings in lungs showed that infection of ferrets produced residual lung lesions not seen in both mock and vaccinated ferrets. SARS-CoV infection demonstrated bronchial and bronchiolar hyperplasia and perivascular cuffing in ferret lung tissue, as seen previously in infected mice. No evidence of enhanced disease was observed in any of the ferrets. All of the ferrets cleared the virus by day 14, 1 week earlier if vaccinated. Conclusions. The vaccine provided mild immune protection to the ferrets after challenge; however, there was no evidence of enhanced liver or lung disease induced by the inactivated whole-virus vaccine. The ferret may provide another useful model for evaluating SARS vaccine safety and efficacy.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Maryland</li></region></list><tree><noCountry><name sortKey="Darnell, Miriam E R" sort="Darnell, Miriam E R" uniqKey="Darnell M" first="Miriam E. R." last="Darnell">Miriam E. R. Darnell</name><name sortKey="Plant, Ewan P" sort="Plant, Ewan P" uniqKey="Plant E" first="Ewan P." last="Plant">Ewan P. Plant</name><name sortKey="Ward, Jerrold M" sort="Ward, Jerrold M" uniqKey="Ward J" first="Jerrold M." last="Ward">Jerrold M. Ward</name><name sortKey="Watanabe, Hisayoshi" sort="Watanabe, Hisayoshi" uniqKey="Watanabe H" first="Hisayoshi" last="Watanabe">Hisayoshi Watanabe</name></noCountry><country name="États-Unis"><region name="Maryland"><name sortKey="Byrum, Russ" sort="Byrum, Russ" uniqKey="Byrum R" first="Russ" last="Byrum">Russ Byrum</name></region><name sortKey="St Claire, Marisa" sort="St Claire, Marisa" uniqKey="St Claire M" first="Marisa" last="St. Claire">Marisa St. Claire</name><name sortKey="Taylor, Deborah R" sort="Taylor, Deborah R" uniqKey="Taylor D" first="Deborah R." last="Taylor">Deborah R. Taylor</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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